I recently came across this particular issue when building out a new environment for a customer based upon the now legacy Windows Server 2008 R2 session hosts. When in UAT we discovered that existing profiles were not loading and within the event log the following was noted.
The Citrix Profile Management driver could not be loaded. Processing cannot continue. The user will be given a temporary profile. Cause: The Citrix Profile Management Service on this computer could not connect to the driver while processing a user logon. Action: Restart the machine. If the problem persists, uninstall and reinstall Citrix Profile management.
From Citrix XenApp and XenDesktop 7.11 onwards UPM is now updated to use SHA256 signatures which Server 2008 R2 does not without an update.
To rectify this crack open your master image again and install either through windows update or a direct download update 3033929 https://technet.microsoft.com/en-us/library/security/3033929.aspx .
Once installed reboot the image and then reinstall the Citrix VDA and roll out the updated image again making sure you clear out any non critical user profiles within the master image first.
Author: Dale Scriven